drug effects human Humans 190 controlled study 140 metabolism 134 Article 124 Animals 114 animal 114 nonhuman 96 unclassified drug 96 human cell 92 genetics 74 priority journal 70 chemistry 68 mouse 56 female 54 protein expression 54 Mice 46 Female 44 animal cell 44 in vitro study 44 apoptosis 42 pathology 42 signal transduction 42 Cell Line, Tumor 40 cell proliferation 40 male 40 tumor cell line 40 animal experiment 38 cell line 38