Article human Humans 486 controlled study 461 priority journal 330 nonhuman 309 metabolism 274 human cell 254 female 245 Animals 214 male 213 animal 210 unclassified drug 194 Female 181 genetics 174 adult 173 Male 153 protein expression 148 drug effects 124 chemistry 118 animal cell 112 in vitro study 112 mouse 112 physiology 108 animal experiment 102 signal transduction 96 pathology 88 Adult 81 Argentina 78 major clinical study 78