Animals controlled study human Humans 481 nonhuman 474 article 383 priority journal 335 human cell 327 animal cell 294 animal 279 Mice 272 mouse 265 unclassified drug 236 animal experiment 202 metabolism 199 protein expression 191 female 165 Female 162 Article 154 animal model 146 male 126 Male 124 genetics 116 animal tissue 110 in vitro study 106 Cell Line 96 in vivo study 93 cell proliferation 92 Cell Line, Tumor 91 signal transduction 89