controlled study human 93 human cell priority journal protein function article 77 Humans 76 protein expression 48 nonhuman 45 Animals 36 animal cell 30 signal transduction 28 unclassified drug 28 Mice 25 mouse 25 Cell Line 23 Cell Line, Tumor 23 genetics 23 metabolism 23 cell proliferation 22 protein protein interaction 22 Female 21 messenger RNA 19 protein localization 19 animal experiment 18 female 18 enzyme activity 17 gene expression 17 regulatory mechanism 17 Article 16