controlled study human 129 human cell mouse priority journal nonhuman 125 Animals 109 animal cell 101 Mice 100 Humans 95 article 93 animal experiment 81 animal model 66 protein expression 65 unclassified drug 53 female 41 animal 40 animal tissue 39 male 38 Female 37 signal transduction 37 cell proliferation 36 in vitro study 34 metabolism 34 in vivo study 33 Article 32 Cell Line, Tumor 28 protein protein interaction 27 Cell Proliferation 26 protein function 25