controlled study human human cell Humans 701 article 691 priority journal 612 nonhuman 386 unclassified drug 337 Animals 327 protein expression 314 animal cell 262 metabolism 245 Article 236 female 236 Female 212 mouse 207 cell proliferation 199 signal transduction 191 Mice 186 male 182 Cell Line, Tumor 178 in vitro study 172 Cell Line 159 apoptosis 159 Male 144 animal experiment 140 enzyme activity 129 animal 125 protein function 121 Apoptosis 112