controlled study human major clinical study female 170 adult 159 male 157 Humans 151 article 144 priority journal 136 Female 135 Male 129 Adult 106 Middle Aged 95 aged 76 Aged 62 Argentina 60 Article 60 adolescent 39 middle aged 37 Adolescent 35 nonhuman 31 child 29 disease severity 27 human cell 25 Child 24 human tissue 23 risk factor 23 Case-Control Studies 22 Animals 21 genotype 21