controlled study female human 149 major clinical study male adult 127 Female 113 Male 113 Humans 105 priority journal 98 article 95 Adult 81 Middle Aged 73 aged 60 Article 46 Argentina 45 Aged 42 middle aged 35 adolescent 33 Adolescent 29 child 23 Child 20 disease severity 18 Case-Control Studies 16 disease association 16 Alzheimer disease 14 Treatment Outcome 14 Young Adult 14 risk factor 14 metabolism 13