chemistry synthesis article 82 chemical structure 72 unclassified drug 69 nonhuman 51 Article 50 human 50 Molecular Structure 48 Humans 46 controlled study 44 metabolism 43 Animals 40 animal 40 drug effects 32 drug synthesis 32 Models, Molecular 26 priority journal 26 X ray crystallography 25 human cell 24 Crystallography, X-Ray 23 hydrogen bond 23 conformation 22 structure activity relation 22 ligand 19 Structure-Activity Relationship 18 cell proliferation 18 drug screening 18 molecular docking 18 nuclear magnetic resonance spectroscopy 17