article enzyme activity human 115 human cell controlled study 101 Humans 80 priority journal 69 protein expression 37 Animals 34 signal transduction 33 cell proliferation 30 nonhuman 30 unclassified drug 29 Cell Line, Tumor 27 Mice 25 metabolism 24 mouse 24 animal cell 22 apoptosis 21 enzyme activation 21 enzyme inhibition 19 Female 18 Male 18 protein function 17 Mus 16 male 16 Cell Line 15 Western blotting 15 Cell Proliferation 13 Enzyme Activation 13