article controlled study priority journal signal transduction nonhuman 239 Animals 191 animal cell 167 human 117 mouse 116 protein expression 113 Mice 110 Humans 97 Signal Transduction 95 human cell 95 female 93 animal tissue 92 animal experiment 90 Female 88 cell proliferation 68 unclassified drug 65 enzyme activity 63 male 62 rat 60 metabolism 59 protein phosphorylation 59 enzyme activation 57 Rats 56 Male 53 animal model 50 phosphatidylinositol 3 kinase 48