Article controlled study nonhuman 926 priority journal 619 metabolism 592 Animals 590 animal 580 human 461 animal experiment 412 female 397 male 393 unclassified drug 380 Humans 349 animal cell 320 animal tissue 314 mouse 306 genetics 302 drug effects 292 physiology 284 Female 275 Male 275 adult 265 protein expression 246 human cell 236 chemistry 202 Mice 196 animal model 184 in vitro study 182 enzyme activity 156 signal transduction 142