Article animal experiment animal model animal tissue controlled study male nonhuman 58 mouse 50 priority journal 34 Animals 32 animal 32 Mice 28 Male 26 metabolism 26 animal cell 22 protein expression 22 female 20 human 18 drug effects 16 pathology 16 adult 14 enzyme activity 14 in vitro study 14 cell proliferation 12 gene expression 12 human cell 12 immunohistochemistry 12 in vivo study 12 messenger RNA 12 upregulation 12