Animals animal experiment male nonhuman controlled study 642 Male 641 article 533 priority journal 508 animal tissue 376 mouse 309 Mice 302 animal model 277 animal 270 female 263 animal cell 239 Female 220 Article 196 rat 188 Rats 172 metabolism 167 protein expression 164 physiology 146 unclassified drug 112 Humans 98 adult 97 drug effect 95 drug effects 94 enzyme activity 88 human 88 Rats, Sprague-Dawley 86