Animals animal experiment enzyme activity metabolism nonhuman 66 animal 62 controlled study 62 priority journal 42 animal tissue 41 Article 40 mouse 31 Mice 29 male 29 article 26 unclassified drug 24 drug effects 22 physiology 22 Male 21 animal model 21 animal cell 20 protein expression 20 Water Pollutants, Chemical 18 female 18 toxicity 18 enzymology 17 pathology 17 water pollutant 16 Female 14 enzyme inhibition 14 glutathione 14