article enzyme activity priority journal unclassified drug nonhuman 133 controlled study 110 Animals 59 protein expression 43 animal experiment 36 animal tissue 31 protein function 30 Humans 26 Trypanosoma cruzi 26 mouse 26 human 23 animal cell 22 enzyme inhibition 22 signal transduction 22 metabolism 21 Mice 19 enzyme substrate 19 Enzymes 18 Proteins 18 Trypanosoma 17 male 17 Kinetics 16 Molecular Sequence Data 16 Protein Binding 16 Saccharomyces cerevisiae 16 Substrate Specificity 16