Male controlled study male 183 metabolism nonhuman Animals 181 animal 181 animal experiment 143 priority journal 127 Article 126 animal tissue 100 physiology 92 mouse 91 animal cell 80 Mice 75 female 69 drug effects 67 protein expression 67 Female 61 genetics 61 article 57 animal model 52 adult 50 unclassified drug 47 drug effect 39 gene expression 39 in vitro study 39 pathology 37 signal transduction 33 human 32