Humans article unclassified drug human 341 controlled study 313 priority journal 275 nonhuman 273 Animals 257 human cell 238 animal cell 141 protein expression 128 Mice 121 mouse 98 Cell Line 90 Cell Line, Tumor 87 metabolism 82 protein function 67 Protein Binding 66 Female 63 in vitro study 62 signal transduction 62 animal 61 cell proliferation 58 chemistry 57 animal experiment 56 female 55 Male 52 drug structure 52 messenger RNA 50 nucleotide sequence 50