Animals animal 377 drug effects nonhuman 277 controlled study 249 Article 232 metabolism 231 animal experiment 160 priority journal 153 male 137 mouse 133 animal cell 125 physiology 119 human 114 Male 113 female 113 Humans 112 unclassified drug 112 Mice 111 animal tissue 101 genetics 94 Female 91 chemistry 88 animal model 74 in vitro study 67 protein expression 65 article 55 toxicity 54 dose response 53 adult 50