Animals animal 181 drug effects metabolism nonhuman controlled study 169 Article 152 animal experiment 118 priority journal 105 mouse 97 male 91 animal tissue 89 animal cell 87 Mice 77 female 77 Male 67 unclassified drug 64 protein expression 59 Female 57 animal model 56 physiology 55 genetics 52 human 52 Humans 50 in vitro study 43 adult 42 signal transduction 36 enzyme activity 34 in vivo study 34 pathology 34