article priority journal unclassified drug nonhuman 396 controlled study 323 Animals 232 animal cell 161 Humans 124 human 120 protein expression 105 Mice 95 mouse 91 animal experiment 84 animal tissue 79 enzyme activity 73 human cell 73 male 66 female 65 rat 64 protein function 63 Male 62 Molecular Sequence Data 60 Rats 60 Female 59 Trypanosoma cruzi 52 nucleotide sequence 48 Amino Acid Sequence 46 animal model 44 metabolism 42 signal transduction 42