Animals controlled study human Humans 228 nonhuman 226 article 178 priority journal 160 human cell 154 animal cell 139 animal 134 Mice 128 mouse 125 unclassified drug 112 animal experiment 98 metabolism 94 protein expression 89 female 80 Female 78 Article 77 animal model 71 male 61 Male 60 genetics 55 animal tissue 53 in vitro study 51 Cell Line 45 in vivo study 44 cell proliferation 43 Cell Line, Tumor 42 signal transduction 42