algorithm 7 article 7 Algorithms 6 Calcium 6 Calcium Signaling 6 Inositol 1,4,5-Trisphosphate 6 Models, Biological 6 biological model 6 calcium 6 calcium signaling 6 inositol 1,4,5 trisphosphate 6 metabolism 6 physiology 6 Neptunia 4 Puffs 4 calcium ion 4 inositol 1,4,5 trisphosphate receptor 4 statistical model 4 Animals 3 Buffers 3 Calcium Channels 3 Cell Membrane 3 Computer Simulation 3 Cytosol 3 Dose-Response Relationship, Drug 3 Endoplasmic Reticulum 3 High resolution 3 Humans 3 Inositol 1,4,5-Trisphosphate Receptors 3 Ion Channel Gating 3