E3 ligase 4 Humans 4 SUMO protein 4 SUMO-1 Protein 4 Tumor Suppressor Protein p53 4 article 4 controlled study 4 enzyme activity 4 human 4 human cell 4 priority journal 4 protein function 4 protein p53 4 signal transduction 4 sumoylation 4 ubiquitin protein ligase E3 4 Cell Line 3 Heat-Shock Response 3 Nuclear Proteins 3 Posttranslational modification 3 Protein Binding 3 RNA 3 RNA binding protein 3 RNA metabolism 3 RNA processing 3 RNA splicing 3 RNA, Small Interfering 3 RNA-Binding Proteins 3 SUMO 1 protein 3 SUMO E3 ligase 3