Humans 4 Molecular dynamics 4 Oxygen 4 article 4 molecular dynamics 4 oxygen 4 priority journal 4 protein conformation 4 Active site 3 Amino acids 3 Animals 3 Conceptual frameworks 3 Conformations 3 Energy profile 3 Histidine 3 Histidine residues 3 Hydrogen-Ion Concentration 3 Hydrophobic and Hydrophilic Interactions 3 Hydrophobic effect 3 Hydrophobic sites 3 Hydrophobicity 3 Ligands 3 Molecular dynamics simulations 3 Myoglobin 3 Open conformation 3 Oxygen migration 3 Oxygen uptake 3 Protein Binding 3 Protein Structure, Secondary 3 Protonation 3