Amino Acid Motifs 1 Amino acids 1 Article 1 Binding energy 1 Bins 1 Catalysis 1 Conformations 1 Crystal structure 1 Crystallography, X-Ray 1 Enzyme activity 1 Humans 1 Hydrogen bonding interactions 1 Hydrogen bonds 1 Indoleamine 2 ,3-dioxygenase 1 Indoleamine-Pyrrole 2,3,-Dioxygenase 1 Molecular dynamics 1 Mutagenesis Mutagenesis, Site-Directed 1 Post-translational modifications 1 Protein Domains 1 Protein-protein interactions 1 Proteins 1 Replica-exchange molecular dynamics simulations 1 Site directed mutagenesis 1 Structural rearrangement 1 Structure and dynamics 1 Structure-Activity Relationship 1 X ray crystallography 1 binding site 1 cancer therapy 1