Information content in stochastic pulse sequences of intracellular messengers
Many cell signaling pathways rely on oscillatory messenger concentrations even to transduce aperiodic environmental changes. The universal second messenger calcium, Ca2+ often exhibits pulsatile behavior in the presence of constant concentrations of external ligands such as hormones or neurotransmit...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_2296424X_v6_nJUL_p_Givre |
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todo:paper_2296424X_v6_nJUL_p_Givre2023-10-03T16:40:45Z Information content in stochastic pulse sequences of intracellular messengers Givré, A. Dawson, S.P. Ca2+ pulses Cell signaling Information Inhibition Poisson processes Many cell signaling pathways rely on oscillatory messenger concentrations even to transduce aperiodic environmental changes. The universal second messenger calcium, Ca2+ often exhibits pulsatile behavior in the presence of constant concentrations of external ligands such as hormones or neurotransmitters. The analysis of intracellular Ca2+ pulses that involve Ca2+ release through inositol 1,4,5-trisphosphate (IP3) receptors led to a model with stochastic pulse firing at rate, λ and deterministic inhibition with recovery at rate, ρ. Here we combine this model with recent observations that established an exponential relationship between λ and the external ligand concentration, C. We compute analytically the mutual information between C and the interpulse time, t, or the number of pulses, N, in the λ/ρ ≪ 1 and λ/ρ ≫ 1 limits. We obtain that both I(C, t) and I(C, N) are largest in the second limit with a difference of at most ~1bit. Thus, the resolution with which the values of C can be discriminated at most doubles in one limit with respect to the other. The components of the model and the exponential dependence of the firing rate with C are features common to noise-driven excitable systems. Our results thus hold in this more general setting that applies widely in biology. © 2018 Givré and Ponce Dawson. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_2296424X_v6_nJUL_p_Givre |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Ca2+ pulses Cell signaling Information Inhibition Poisson processes |
| spellingShingle |
Ca2+ pulses Cell signaling Information Inhibition Poisson processes Givré, A. Dawson, S.P. Information content in stochastic pulse sequences of intracellular messengers |
| topic_facet |
Ca2+ pulses Cell signaling Information Inhibition Poisson processes |
| description |
Many cell signaling pathways rely on oscillatory messenger concentrations even to transduce aperiodic environmental changes. The universal second messenger calcium, Ca2+ often exhibits pulsatile behavior in the presence of constant concentrations of external ligands such as hormones or neurotransmitters. The analysis of intracellular Ca2+ pulses that involve Ca2+ release through inositol 1,4,5-trisphosphate (IP3) receptors led to a model with stochastic pulse firing at rate, λ and deterministic inhibition with recovery at rate, ρ. Here we combine this model with recent observations that established an exponential relationship between λ and the external ligand concentration, C. We compute analytically the mutual information between C and the interpulse time, t, or the number of pulses, N, in the λ/ρ ≪ 1 and λ/ρ ≫ 1 limits. We obtain that both I(C, t) and I(C, N) are largest in the second limit with a difference of at most ~1bit. Thus, the resolution with which the values of C can be discriminated at most doubles in one limit with respect to the other. The components of the model and the exponential dependence of the firing rate with C are features common to noise-driven excitable systems. Our results thus hold in this more general setting that applies widely in biology. © 2018 Givré and Ponce Dawson. |
| format |
JOUR |
| author |
Givré, A. Dawson, S.P. |
| author_facet |
Givré, A. Dawson, S.P. |
| author_sort |
Givré, A. |
| title |
Information content in stochastic pulse sequences of intracellular messengers |
| title_short |
Information content in stochastic pulse sequences of intracellular messengers |
| title_full |
Information content in stochastic pulse sequences of intracellular messengers |
| title_fullStr |
Information content in stochastic pulse sequences of intracellular messengers |
| title_full_unstemmed |
Information content in stochastic pulse sequences of intracellular messengers |
| title_sort |
information content in stochastic pulse sequences of intracellular messengers |
| url |
http://hdl.handle.net/20.500.12110/paper_2296424X_v6_nJUL_p_Givre |
| work_keys_str_mv |
AT givrea informationcontentinstochasticpulsesequencesofintracellularmessengers AT dawsonsp informationcontentinstochasticpulsesequencesofintracellularmessengers |
| _version_ |
1807317297959796736 |