Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer

Aberrant DNA methylation observed in cancer can provide survival benefits to cells by silencing genes essential for anti-tumor activity. DNA-demethylating agents such as Decitabine (DAC)/Azacitidine (AZA) activate otherwise silenced tumor suppressor genes, alter immune response and epigenetically re...

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Detalles Bibliográficos
Autores principales:	Ramakrishnan, S., Hu, Q., Krishnan, N., Wang, D., Smit, E., Granger, V., Rak, M., Attwood, K., Johnson, C., Morrison, C., Pili, R., Chatta, G., Guru, K., Gueron, G., McNally, L., Wang, J., Woloszynska-Read, A.
Formato:	JOUR
Materias:	beta galactosidase decitabine double stranded RNA interleukin 6 messenger RNA Notch1 receptor protein p16 transcriptome antineoplastic antimetabolite azacitidine cyclin dependent kinase inhibitor 2A cytokeratin 5 IL6 protein, human monoclonal antibody NOTCH1 protein, human P16 protein, human Article cancer patient cell proliferation cell size cell structure controlled study cytokine release disease marker DNA methylation drug blood level gene overexpression HT-1376 cell line human human cell MDA-MB-231/B02 cell line muscle invasive bladder cancer priority journal T24 cell line transcriptomics analogs and derivatives antagonists and inhibitors bladder tumor gene expression regulation genetic epigenesis genetics immunology metabolism pathology signal transduction smooth muscle treatment outcome tumor cell line tumor invasion Antibodies, Monoclonal Antimetabolites, Antineoplastic Azacitidine beta-Galactosidase Cell Line, Tumor Cyclin-Dependent Kinase Inhibitor p16 Epigenesis, Genetic Gene Expression Regulation, Neoplastic Humans Interleukin-6 Keratin-5 Muscle, Smooth Neoplasm Invasiveness Receptor, Notch1 Signal Transduction Treatment Outcome Urinary Bladder Neoplasms
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_20414889_v8_n12_p_Ramakrishnan
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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