H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway

Nitroxyl (HNO) is a redox sibling of nitric oxide (NO) that targets distinct signalling pathways with pharmacological endpoints of high significance in the treatment of heart failure. Beneficial HNO effects depend, in part, on its ability to release calcitonin gene-related peptide (CGRP) through an...

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Detalles Bibliográficos
Autores principales:	Eberhardt, M., Dux, M., Namer, B., Miljkovic, J., Cordasic, N., Will, C., Kichko, T.I., De La Roche, J., Fischer, M., Suárez, S.A., Bikiel, D., Dorsch, K., Leffler, A., Babes, A., Lampert, A., Lennerz, J.K., Jacobi, J., Martí, M.A., Doctorovich, F., Högestätt, E.D., Zygmunt, P.M., Ivanovic-Burmazovic, I., Messlinger, K., Reeh, P., Filipovic, M.R.
Formato:	JOUR
Materias:	calcitonin gene related peptide hydrogen sulfide nitric oxide nitroxyl transient receptor potential channel A1 unclassified drug nitrogen oxide transient receptor potential channel Trpa1 protein, mouse amino terminal sequence animal cell article blood pressure blood vessel tone calcium transport cerebrospinal fluid controlled study disulfide bond electrophilicity female human immunoprecipitation immunoreactivity male mast cell degranulation matrix assisted laser desorption ionization time of flight mass spectrometry mean arterial pressure mouse nonhuman regulatory mechanism sensory nerve cell signal transduction spinal ganglion vasodilatation animal aorta brain stem drug effects genetics immunohistochemistry in vitro study knockout mouse mass spectrometry metabolism trigeminus ganglion Animals Aorta Brain Stem Calcitonin Gene-Related Peptide Humans Hydrogen Sulfide Immunohistochemistry In Vitro Techniques Mice Mice, Knockout Nitric Oxide Nitrogen Oxides Signal Transduction Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Transient Receptor Potential Channels Trigeminal Ganglion
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_20411723_v5_n_p_Eberhardt
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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