Autocrine IL-6 mediates pituitary tumor senescence

Cellular senescence is a stable proliferative arrest state. Pituitary adenomas are frequent and mostly benign, but the mechanism for this remains unknown. IL-6 is involved in pituitary tumor progression and is produced by the tumoral cells. In a cell autonomous fashion, IL-6 participates in oncogene...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Sapochnik, M., Haedo, M.R., Fuertes, M., Ajler, P., Carrizo, G., Cervio, A., Sevlever, G., Stalla, G.K., Arzt, E.
Formato: JOUR
Materias:
Autocrine
Benign tumor
IL-6
Pituitary tumor
Senescence
beta galactosidase
cyclin dependent kinase inhibitor 2A
growth hormone
interleukin 6
senescence associated beta galactosidase
short hairpin RNA
tumor marker
unclassified drug
animal experiment
animal model
animal tissue
Article
autocrine effect
carcinogenicity
cell aging
cell culture
cell invasion
cell proliferation
controlled study
enzyme activity
enzyme analysis
gene expression
gene silencing
human
human cell
human tissue
hypophysis adenoma
hypophysis tumor
in vitro study
in vivo study
interferon production
male
molecular cloning
mouse
nonhuman
pathogenesis
phenotype
protein expression
senescence
wild type
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19492553_v8_n3_p4690_Sapochnik
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Ejemplares similares