Glypican-3 induces a mesenchymal to epithelial transition in human breast cancer cells

Breast cancer is the disease with the highest impact on global health, being metastasis the main cause of death. To metastasize, carcinoma cells must reactivate a latent program called epithelial-mesenchymal transition (EMT), through which epithelial cancer cells acquire mesenchymal-like traits. Gly...

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Detalles Bibliográficos
Autores principales:	Castillo, L.F., Tascón, R., Huvelle, M.A.L., Novack, G., Llorens, M.C., Santos, A.F., Shortrede, J., Cabanillas, A.M., Joffé, E.B.K., Labriola, L., Peters, M.G.
Formato:	JOUR
Materias:	Breast cancer Epithelial-mesenchymal transition Glypican-3 Invasion Metastasis beta catenin glypican 3 nerve cell adhesion molecule uvomorulin Wnt protein cadherin glypican GPC3 protein, human transcription factor ZEB1 ZEB1 protein, human animal experiment animal model animal tissue apoptosis Article breast cancer breast cancer cell line cancer cell cell death cell growth cell invasion cell migration cell structure cell viability controlled study down regulation epithelial mesenchymal transition female histopathology human human cell immunofluorescence immunohistochemistry in vitro study in vivo study MCF 7 cell line MDA MB231 cell line metastasis potential mouse nonhuman protein expression real time polymerase chain reaction tumor xenograft upregulation Western blotting ZR 75 1 cell line animal breast tumor cell motion cell proliferation gene expression regulation genetics MCF-7 cell line metabolism nude mouse pathology RNA interference tumor cell line tumor volume xenograft Animals Breast Neoplasms Cadherins Cell Line, Tumor Cell Movement Cell Proliferation Epithelial-Mesenchymal Transition Female Gene Expression Regulation, Neoplastic Glypicans Humans MCF-7 Cells Mice, Nude RNA Interference Transplantation, Heterologous Tumor Burden Zinc Finger E-box-Binding Homeobox 1
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_19492553_v7_n37_p60133_Castillo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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