CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response

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DNA damage triggers a phosphorylation-based signaling cascade known as the DNA damage response. p19INK4d, a member of the INK4 family of CDK4/6 inhibitors, has been reported to participate in the DNA damage response promoting DNA repair and cell survival. Here, we provide mechanistic insight into th...

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Detalles Bibliográficos
Autores principales: Marazita, M.C., Florencia Ogara, M., Sonzogni, S.V., Martí, M., Dusetti, N.J., Pignataro, O.P., Cánepa, E.T.
Formato: JOUR
Materias:
amyloid beta protein
ATM protein
ATR protein
checkpoint kinase 1
checkpoint kinase 2
cisplatin
cyclic AMP dependent protein kinase
cyclin dependent kinase 2
cyclin dependent kinase 4
cyclin dependent kinase 6
cyclin dependent kinase inhibitor 2D
phosphate p 32
serine
threonine
CDK2 protein, human
DNA
article
cell nucleus
cell survival
conformational transition
controlled study
DNA damage
DNA repair
point mutation
protein phosphorylation
signal transduction
ultraviolet radiation
cell cycle
cell line
cell strain HEK293
drug effect
gene expression regulation
genetics
human
metabolism
mutation
phosphorylation
protein transport
radiation exposure
Amyloid beta-Peptides
Cell Cycle
Cell Line
Cell Survival
Cisplatin
Cyclic AMP-Dependent Protein Kinases
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinase Inhibitor p19
DNA Damage
DNA Repair
Gene Expression Regulation
HEK293 Cells
Humans
Mutation
Phosphorylation
Protein Transport
Signal Transduction
Ultraviolet Rays
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19326203_v7_n4_p_Marazita
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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