Inhibition of Cell Division Induced by External Guide Sequences (EGS Technology) Targeting ftsZ

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EGS (external guide sequence) technology is a promising approach to designing new antibiotics. EGSs are short antisense oligoribonucleotides that induce RNase P-mediated cleavage of a target RNA by forming a precursor tRNA-like complex. The ftsZ mRNA secondary structure was modeled and EGSs compleme...

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Detalles Bibliográficos
Autores principales: Sala, C.D., Soler-Bistué, A.J.C., Korprapun, L., Zorreguieta, A., Tolmasky, M.E.
Formato: JOUR
Materias:
messenger RNA
ribonuclease P
transfer RNA
article
bacterial cell
binding affinity
binding site
complex formation
controlled study
Escherichia coli
experimental design
external guide sequence technology
ftsZ gene
gene
gene targeting
gene technology
growth inhibition
in vitro study
mitosis inhibition
nonhuman
promoter region
protein secondary structure
recombinant plasmid
RNA binding
RNA cleavage
RNA structure
sequence analysis
Anti-Bacterial Agents
Bacterial Proteins
Base Sequence
Cell Division
Cytoskeletal Proteins
Drug Design
Electrophoretic Mobility Shift Assay
Microscopy, Confocal
Molecular Sequence Data
Nucleic Acid Conformation
Oligoribonucleotides, Antisense
Promoter Regions, Genetic
Ribonuclease P
RNA Cleavage
Terminator Regions, Genetic
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19326203_v7_n10_p_Sala
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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