New human papilloma virus E2 transcription factor mimics: A tripyrrole-peptide conjugate with tight and specific DNA-recognition

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Background: Human papillomavirus (HPV) is the main causative agent of cervical cancer, particularly high risk strains such us HPV-16, -18 and -31. The viral encoded E2 protein acts as a transcriptional modulator and exerts a key role in viral DNA replication. Thus, E2 constitutes an attractive targe...

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Detalles Bibliográficos
Autores principales: Wetzler, D.E., Comin, M.J., Krajewski, K., Gallo, M.
Formato: JOUR
Materias:
distamycin A
DNA
peptide
protein E2
transcription factor
unclassified drug
antivirus agent
biomimetic material
DNA binding protein
E2 protein, Human papillomavirus type 16
oncoprotein
peptide fragment
pyrrole derivative
virus DNA
alpha helix
article
circular dichroism
computer model
conjugation
DNA synthesis
gel mobility shift assay
Human papillomavirus type 16
nonhuman
nuclear magnetic resonance spectroscopy
protein DNA binding
protein interaction
protein structure
amino acid sequence
chemical structure
chemistry
enzyme specificity
genetics
metabolism
molecular genetics
nucleotide sequence
papillomavirus infection
physiology
protein secondary structure
synthesis
Human papillomavirus
Amino Acid Sequence
Antiviral Agents
Base Sequence
Biomimetic Materials
Distamycins
DNA, Viral
DNA-Binding Proteins
Human papillomavirus 16
Models, Molecular
Molecular Sequence Data
Oncogene Proteins, Viral
Papillomavirus Infections
Peptide Fragments
Protein Structure, Secondary
Pyrroles
Substrate Specificity
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19326203_v6_n7_p_Wetzler
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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