Insights on glucocorticoid receptor activity modulation through the binding of rigid steroids

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Background: The glucocorticoid receptor (GR) is a transcription factor that regulates gene expression in a ligand-dependent fashion. This modular protein is one of the major pharmacological targets due to its involvement in both cause and treatment of many human diseases. Intense efforts have been m...

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Detalles Bibliográficos
Autores principales: Presman, D.M., Alvarez, L.D., Levi, V., Eduardo, S., Digman, M.A., Martí, M.A., Veleiro, A.S., Burton, G., Pecci, A.
Formato: JOUR
Materias:
21 hemisuccinate 6,19 epoxyprogesterone
21 hydroxy 6,19 epoxyprogesterone
dexamethasone
glucocorticoid receptor
glucocorticoid receptor antagonist
mifepristone
nuclear receptor coactivator 2
unclassified drug
DNA
steroid
article
binding affinity
cell assay
cell culture
cell strain BHK
cell strain COS7
cell strain L 929
cell type
computer model
conformational transition
controlled study
dissociation
DNA drug complex
drug mechanism
drug receptor binding
genetic transfection
in vitro study
in vivo study
incubation time
ligand binding
modulation
molecular dynamics
oligomerization
protein DNA binding
protein DNA interaction
protein function
steroid binding
structure activity relation
animal
cell line
cell strain COS1
Cercopithecus
chemical structure
dimerization
gel mobility shift assay
immunoprecipitation
metabolism
protein binding
Animals
Cell Line
Cercopithecus aethiops
COS Cells
Dimerization
Electrophoretic Mobility Shift Assay
Immunoprecipitation
Models, Molecular
Molecular Dynamics Simulation
Protein Binding
Receptors, Glucocorticoid
Steroids
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19326203_v5_n10_p_Presman
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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