Structural coalescence underlies the aggregation propensity of a β-barrel protein motif

A clear understanding of the structural foundations underlying protein aggregation is an elusive goal of central biomedical importance. A step toward this aim is exemplified by the β- barrel motif represented by the intestinal fatty acid binding protein (IFABP) and two abridged all-β sheet forms (δ9...

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Detalles Bibliográficos
Autores principales: Angelani, C.R., Caramelo, J.J., Curto, L.M., Delfino, J.M.
Formato: JOUR
Materias:
fatty acid binding protein
trifluoroethanol
urea
protein aggregate
aqueous solution
Article
beta sheet
carboxy terminal sequence
circular dichroism
correlational study
protein aggregation
protein conformation
protein motif
protein secondary structure
protein stability
protein unfolding
structure analysis
animal
chemistry
metabolism
rat
Amino Acid Motifs
Animals
Fatty Acid-Binding Proteins
Protein Aggregates
Protein Stability
Rats
Trifluoroethanol
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19326203_v12_n2_p_Angelani
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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