Molecular dynamics simulations of the glucocorticoid receptor DNA-binding domain suggest a role of the lever-arm mobility in transcriptional output

One of the first and essential steps in gene expression regulation involves the recruitment of transcription factors (TFs) to specific response elements located at enhancers and/or promoters of targeted genes. These DNA elements have a certain variability in both sequence and length, which may affec...

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Detalles Bibliográficos
Autores principales: Álvarez, L.D., Presman, D.M., Pecci, A.
Formato: JOUR
Materias:
DNA
glucocorticoid receptor
transcription factor
coordination compound
protein binding
zinc
amino acid substitution
Article
dimerization
DNA structure
molecular dynamics
molecular mechanics
nonhuman
protein DNA binding
protein DNA interaction
protein domain
wild type
amino acid sequence
animal
binding site
chemistry
conformation
genetic transcription
hydrogen bond
promoter region
protein multimerization
protein quaternary structure
rat
Amino Acid Sequence
Animals
Binding Sites
Coordination Complexes
Hydrogen Bonding
Molecular Dynamics Simulation
Nucleic Acid Conformation
Promoter Regions, Genetic
Protein Binding
Protein Interaction Domains and Motifs
Protein Multimerization
Protein Structure, Quaternary
Rats
Receptors, Glucocorticoid
Transcription, Genetic
Zinc
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19326203_v12_n12_p_Alvarez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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