Prediction of spontaneous protein deamidation from sequence-derived secondary structure and intrinsic disorder

Asparagine residues in proteins undergo spontaneous deamidation, a post-translational modification that may act as a molecular clock for the regulation of protein function and turnover. Asparagine deamidation is modulated by protein local sequence, secondary structure and hydrogen bonding. We presen...

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Detalles Bibliográficos
Autores principales: Lorenzo, J.R., Alonso, L.G., Sánchez, I.E.
Formato: JOUR
Materias:
asparagine
beta interferon
protein bcl xl
superoxide dismutase
trastuzumab
amide
intrinsically disordered protein
protein bcl x
Saccharomyces cerevisiae protein
amino acid sequence
Article
deamination
DNA damage
glycosylation
learning algorithm
molecular dynamics
NGOME
protein analysis
protein degradation
protein folding
protein metabolism
protein modification
protein purification
protein secondary structure
protein stability
racemization
receiver operating characteristic
sequence analysis
yeast
animal
chemistry
human
metabolism
molecular genetics
procedures
protein processing
software
Amides
Amino Acid Sequence
Animals
Asparagine
bcl-X Protein
Humans
Interferon-beta
Intrinsically Disordered Proteins
Molecular Sequence Data
Protein Processing, Post-Translational
Protein Structure, Secondary
Saccharomyces cerevisiae Proteins
Sequence Analysis, Protein
Software
Superoxide Dismutase
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19326203_v10_n12_p_Lorenzo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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