Psychostimulant-induced testicular toxicity in mice: Evidence of cocaine and caffeine effects on the local dopaminergic system

Several organ systems can be affected by psychostimulant toxicity. However, there is not sufficient evidence about the impact of psychostimulant intake on testicular physiology and catecholaminergic systems. The aim of the present study was to further explore potential toxic consequences of chronic...

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Detalles Bibliográficos
Autores principales:	Gonzalez, C.R., Gonzalez, B., Matzkin, M.E., Muniz, J.A., Cadet, J.L., Garcia-Rill, E., Urbano, F.J., Vitullo, A.D., Bisagno, V.
Formato:	JOUR
Materias:	adenosine A1 receptor caffeine catalase cocaine copper zinc superoxide dismutase cycline dopamine 1 receptor dopamine 2 receptor follitropin receptor glutathione peroxidase luteinizing hormone receptor messenger RNA protein Bax thiobarbituric acid reactive substance tyrosine 3 monooxygenase central stimulant agent dopamine dopamine uptake inhibitor Drd1a protein, mouse DRD2 protein, mouse free radical primer DNA animal cell animal experiment animal model animal tissue Article cell loss cell proliferation cellular distribution controlled study disease association dopaminergic system down regulation gene expression regulation germ cell intoxication Leydig cell lipid peroxidation long term exposure male male genital tract parameters meiotic germs cell mouse nonhuman protein expression psychostimulant induced testicular toxicity seminiferous tubule volume Sertoli cell spermatogonium testis disease transgenic mouse upregulation animal apoptosis C57BL mouse cytoplasm drug effects genetic epigenesis immunohistochemistry metabolism testis Animals Apoptosis Caffeine Cell Proliferation Central Nervous System Stimulants Cocaine Cytoplasm DNA Primers Dopamine Dopamine Uptake Inhibitors Epigenesis, Genetic Free Radicals Glutathione Peroxidase Immunohistochemistry Leydig Cells Male Mice Mice, Inbred C57BL Receptor, Adenosine A1 Receptors, Dopamine D1 Receptors, Dopamine D2 RNA, Messenger Spermatogonia Testis Thiobarbituric Acid Reactive Substances Tyrosine 3-Monooxygenase
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_19326203_v10_n11_p_Gonzalez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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