Role of TGF-β1 in the behavior disorders

Transforming growth factor 1 (TGF-β1) is an anti-inflammatory cytokine that is expressed in different regions of the mammalian brain, and at all developmental ages. This cytokine can modulate neuron differentiation and survival, and also participate in the tissular response to injury. Based on clini...

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Autor principal:	Depino, A.M.
Formato:	JOUR
Materias:	Autism Depression-related behavior Locomotion Neurogenesis Sociability transforming growth factor beta1 autism brain function central nervous system function circadian rhythm corpus striatum depression hippocampus human locomotion neuromodulation nonhuman priority journal protein binding protein expression protein function protein phosphorylation Review schizophrenia signal transduction socialization substantia nigra
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_1878948X_v6_n1_p19_Depino
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_1878948X_v6_n1_p19_Depino
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spelling	todo:paper_1878948X_v6_n1_p19_Depino2023-10-03T16:34:22Z Role of TGF-β1 in the behavior disorders Depino, A.M. Autism Depression-related behavior Locomotion Neurogenesis Sociability transforming growth factor beta1 autism brain function central nervous system function circadian rhythm corpus striatum depression hippocampus human locomotion neuromodulation nonhuman priority journal protein binding protein expression protein function protein phosphorylation Review schizophrenia signal transduction socialization substantia nigra Transforming growth factor 1 (TGF-β1) is an anti-inflammatory cytokine that is expressed in different regions of the mammalian brain, and at all developmental ages. This cytokine can modulate neuron differentiation and survival, and also participate in the tissular response to injury. Based on clinical evidence, different approaches have been used to study the role of TGF-β1 on modulating brain function and behavior. Here, we review evidence showing a role of TGF-β1 in circadian rhythms, locomotion, sociability and depression-related behaviors. For these behaviors, suprachiamatic, hippocampal and cerebellar expression of TGF-β1 have been manipulated. Further studies are required to extend these results to other brain regions and different behaviors, but so far evidence points to a role of TGF-β1 on behavior disorders such as schizophrenia, depression and autism. © 2015 - IOS Press and the authors. All rights reserved. Fil:Depino, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_1878948X_v6_n1_p19_Depino
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Autism Depression-related behavior Locomotion Neurogenesis Sociability transforming growth factor beta1 autism brain function central nervous system function circadian rhythm corpus striatum depression hippocampus human locomotion neuromodulation nonhuman priority journal protein binding protein expression protein function protein phosphorylation Review schizophrenia signal transduction socialization substantia nigra
spellingShingle	Autism Depression-related behavior Locomotion Neurogenesis Sociability transforming growth factor beta1 autism brain function central nervous system function circadian rhythm corpus striatum depression hippocampus human locomotion neuromodulation nonhuman priority journal protein binding protein expression protein function protein phosphorylation Review schizophrenia signal transduction socialization substantia nigra Depino, A.M. Role of TGF-β1 in the behavior disorders
topic_facet	Autism Depression-related behavior Locomotion Neurogenesis Sociability transforming growth factor beta1 autism brain function central nervous system function circadian rhythm corpus striatum depression hippocampus human locomotion neuromodulation nonhuman priority journal protein binding protein expression protein function protein phosphorylation Review schizophrenia signal transduction socialization substantia nigra
description	Transforming growth factor 1 (TGF-β1) is an anti-inflammatory cytokine that is expressed in different regions of the mammalian brain, and at all developmental ages. This cytokine can modulate neuron differentiation and survival, and also participate in the tissular response to injury. Based on clinical evidence, different approaches have been used to study the role of TGF-β1 on modulating brain function and behavior. Here, we review evidence showing a role of TGF-β1 in circadian rhythms, locomotion, sociability and depression-related behaviors. For these behaviors, suprachiamatic, hippocampal and cerebellar expression of TGF-β1 have been manipulated. Further studies are required to extend these results to other brain regions and different behaviors, but so far evidence points to a role of TGF-β1 on behavior disorders such as schizophrenia, depression and autism. © 2015 - IOS Press and the authors. All rights reserved.
format	JOUR
author	Depino, A.M.
author_facet	Depino, A.M.
author_sort	Depino, A.M.
title	Role of TGF-β1 in the behavior disorders
title_short	Role of TGF-β1 in the behavior disorders
title_full	Role of TGF-β1 in the behavior disorders
title_fullStr	Role of TGF-β1 in the behavior disorders
title_full_unstemmed	Role of TGF-β1 in the behavior disorders
title_sort	role of tgf-β1 in the behavior disorders
url	http://hdl.handle.net/20.500.12110/paper_1878948X_v6_n1_p19_Depino
work_keys_str_mv	AT depinoam roleoftgfb1inthebehaviordisorders
_version_	1807323137387266048

Role of TGF-β1 in the behavior disorders

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