Structure of the glucocorticoid receptor, a flexible protein that can adapt to different ligands

Crystal structures of the glucocorticoid receptor (GR) ligand binding domain in complex with various agonists and antagonists give us an insight on how ligands are recognized by the receptor and how their structure can affect the behavior of the GR. Interestingly, these structural data show how the...

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Detalles Bibliográficos
Autores principales: Veleiro, A.S., Alvarez, L.D., Eduardo, S.L., Burton, G.
Formato: JOUR
Materias:
Glucocorticoids
Hormones
Nuclear receptors
Protein structures
Steroids
aldosterone
deacylcortivazol
deoxycorticosterone
dexamethasone
dimer
fluticasone furoate
fluticasone propionate
glucocorticoid
glucocorticoid receptor
glucocorticoid receptor antagonist
hydrocortisone
ligand
mifepristone
nuclear receptor coactivator 2
steroid
unclassified drug
agonist
amino terminal sequence
antiinflammatory activity
apoptosis
asthma
autoimmune disease
binding site
carboxy terminal sequence
conformation
crystal structure
dermatitis
diabetes mellitus
drug mechanism
drug receptor binding
gene mutation
hydrophilicity
hydrophobicity
hypertension
immunoregulation
immunosuppressive treatment
leukemia
ligand binding
lymphoma
molecular interaction
molecular recognition
myeloma
obesity
osteoporosis
priority journal
protein binding
protein motif
protein protein interaction
protein structure
rheumatoid arthritis
short survey
Binding Sites
Computer Simulation
Crystallography, X-Ray
Ligands
Protein Structure, Tertiary
Receptors, Glucocorticoid
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_18607179_v5_n5_p649_Veleiro
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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