Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity

Background: It has been shown in experimental and theoretical work that covalently modified signaling cascades naturally exhibit bidirectional signal propagation via a phenomenon known as retroactivity. An important consequence of retroactivity, which arises due to enzyme sequestration in covalently...

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Detalles Bibliográficos
Autores principales:	Wynn, M.L., Ventura, A.C., Sepulchre, J.A., García, H.J., Merajver, S.D.
Formato:	JOUR
Materias:	protein kinase inhibitor article biological model computer simulation metabolism signal transduction systems biology Computer Simulation Metabolic Networks and Pathways Models, Biological Protein Kinase Inhibitors Signal Transduction Systems Biology
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_17520509_v5_n_p_Wynn
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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