Trypanocidal activity of thioamide-substituted imidazoquinolinone: Electrochemical properties and biological effects

Three thioamide-substituted imidazoquinolinone, which possess a heterocyclic center similar to tryptanthrin and are named C1, C2, and C3, were studied regarding (a) their in vitro anti-Trypanosoma cruzi activity, (b) their cytotoxicity and electrochemical behaviour, and (c) their effect on cell viab...

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Detalles Bibliográficos
Autores principales: Frank, F.M., Ciccarelli, A.B., Bollini, M., Bruno, A.M., Batlle, A., Lombardo, M.E.
Formato: JOUR
Materias:
antiparasitic agent
imidazoquinolinone derivative
thioamide
unclassified drug
animal cell
antitrypanosomal activity
apoptosis
article
biological activity
cell viability
controlled study
cytotoxicity
cytotoxicity test
drug activity
electrochemical analysis
epimastigote
IC 50
in vitro study
male
molecular weight
mouse
nonhuman
oxidation reduction state
oxidative stress
priority journal
Trypanosoma cruzi
trypomastigote
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_1741427X_v2013_n_p_Frank
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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