Treatment with a new peroxisome proliferator-activated receptor gamma agonist, pyridinecarboxylic acid derivative, increases angiogenesis and reduces inflammatory mediators in the heart of Trypanosoma cruzi-infected mice

Trypanosoma cruzi infection induces an intense inflammatory response in diverse host tissues. The immune response and the microvascular abnormalities associated with infection are crucial aspects in the generation of heart damage in Chagas disease. Upon parasite uptake, macrophages, which are involv...

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Detalles Bibliográficos
Autores principales: Penas, F.N., Carta, D., Dmytrenko, G., Mirkin, G.A., Modenutti, C.P., Cevey, A.C., Rada, M.J., Ferlin, M.G., Sales, M.E., Goren, N.B.
Formato: JOUR
Materias:
Angiogenesis
Inflammatory mediators, heart fibrosis
Macrophages
New peroxisome proliferator-activated receptor gamma agonist
Trypanosoma cruzi
3 hydroxy 1 methylpyridin 1 Ium 4 carboxylate
arginase 1
CD31 antigen
inducible nitric oxide synthase
interleukin 6
peroxisome proliferator activated receptor gamma
picolinic acid
tumor necrosis factor
unclassified drug
vasculotropin A
angiogenesis
animal cell
animal experiment
animal model
animal tissue
Article
body weight
Chagas disease
controlled study
enzyme linked immunosorbent assay
heart muscle fibrosis
histopathology
inflammation
macrophage
molecular docking
mouse
nonhuman
parasitemia
protein expression
protein structure
real time polymerase chain reaction
reverse transcription polymerase chain reaction
survival rate
Western blotting
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_16643224_v8_nDEC_p_Penas
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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