An insight on targets and patented drugs for chemotherapy of chagas disease

Chagas disease or American Trypanosomiasis, a parasitic infection typically spread by triatomine bugs, affects millions of people throughout Latin America. Current chemotherapy based on the nitroaromatic compounds, benznidazole and nifurtimox provides unsatisfactory results and suffers from consider...

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Detalles Bibliográficos
Autores principales:	Duschak, V.G., Couto, A.S.
Formato:	JOUR
Materias:	Chagas disease Drug targets Natural and synthetic inhibitor compounds Trypanosoma cruzi 2 (2,4 difluorophenyl) 1 [3 [2 [4 (2,2,3,3 tetrafluoropropoxy)phenyl]vinyl] 1,2,4 triazol 1 yl] 3 (1,2,4 triazol 1 yl) 2 propanol 2 [2 (2,4 difluorophenyl) 2 hydroxy 1 methyl 3 (1h 1,2,4 triazol 1 yl)propyl] 4 [4 (2,2,3,3 tetrafluoropropoxy)phenyl] 1,2,4 triazol 3(2h) one albaconazole alendronic acid amiodarone amphotericin B lipid complex aromatic nitro compound benznidazole cathepsin K inhibitor etidronic acid fluconazole imidazole derivative itraconazole ketoconazole mevinolin nifuroxime nifurtimox nitrile pamidronic acid posaconazole proteinase inhibitor pyridinium derivative quinuclidine derivative ravuconazole risedronic acid terbinafine thiocyanic acid derivative thiosemicarbazone derivative tipifarnib unindexed drug biochemistry clinical trial drug design drug efficacy drug potentiation drug structure drug synthesis drug targeting human leishmaniasis malaria nonhuman osteoporosis patent priority journal review sterol synthesis trypanosomiasis Animals Arginine Kinase Biological Products Chagas Disease Enzyme Inhibitors Ergosterol Glycolysis Humans Lipids Organelles Patents as Topic Pentose Phosphate Pathway Protease Inhibitors Purines Sialic Acids Sulfhydryl Compounds Terpenes Trypanocidal Agents
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_1574891X_v2_n1_p19_Duschak
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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