miR-190 Enhances HIF-Dependent Responses to Hypoxia in Drosophila by Inhibiting the Prolyl-4-hydroxylase Fatiga

Cellular and systemic responses to low oxygen levels are principally mediated by Hypoxia Inducible Factors (HIFs), a family of evolutionary conserved heterodimeric transcription factors, whose alpha- and beta-subunits belong to the bHLH-PAS family. In normoxia, HIFα is hydroxylated by specific proly...

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Detalles Bibliográficos
Autores principales: De Lella Ezcurra, A.L., Bertolin, A.P., Kim, K., Katz, M.J., Gándara, L., Misra, T., Luschnig, S., Perrimon, N., Melani, M., Wappner, P.
Formato: JOUR
Materias:
Fatiga
hypoxia inducible factor
hypoxia inducible factor 1alpha
hypoxia inducible factor 1beta
hypoxia inducible factor proline dioxygenase
microRNA
microRNA 190
Sima
transcription factor GAL4
unclassified drug
oxygen
procollagen proline 2 oxoglutarate 4 dioxygenase
3' untranslated region
Article
controlled study
Drosophila melanogaster
embryo
environmental stress
enzyme inhibition
gene interaction
gene overexpression
hypoxia
lethality
loss of function mutation
nonhuman
oxygen supply
phenotype
protein degradation
protein expression
protein function
protein stability
pupa
RNA interference
trachea
animal
biosynthesis
cell hypoxia
gene expression regulation
genetic transcription
genetics
growth, development and aging
human
metabolism
Animals
Cell Hypoxia
Gene Expression Regulation
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
MicroRNAs
Oxygen
Prolyl Hydroxylases
Transcription, Genetic
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_15537390_v12_n5_p_DeLellaEzcurra
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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