Photosensitized cleavage of plasmidic DNA by norharmane, a naturally occurring β-carboline

UV-A radiation (320-400 nm) induces damages to the DNA molecule and its components through photosensitized reactions. β-Carbolines (βCs), heterocyclic compounds widespread in biological systems, participate in several biological processes and are able to act as photosensitizers. The photosensitizati...

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Detalles Bibliográficos
Autores principales:	Gonzalez, M.M., Pellon-Maison, M., Ales-Gandolfo, M.A., Gonzalez-Baró, M.R., Erra-Balsells, R., Cabrerizo, F.M.
Formato:	JOUR
Materias:	Aqueous solutions Biological process Carbolines DNA molecules DNA strand break Effect of pH Electron transfer Electronic excited state Heterocyclic compound Hydroxyl radicals Kinetic study Methyl derivatives Naturally occurring Photocleavage reaction Physiological pH Protonated Reactive oxygen species Singlet oxygen Superoxide anions UVA radiation Cesium Cesium compounds Derivatives DNA Electric excitation Excited states Free radical reactions Genes Oxygen Photosensitizers Reaction intermediates pH effects beta carboline carboline derivative drug derivative harmine water article chemistry DNA adduct DNA damage drug effect light pH photochemistry plasmid solution and solubility spectrophotometry DNA Adducts DNA Damage Harmine Hydrogen-Ion Concentration Light Photochemistry Plasmids Solutions Spectrophotometry Water
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_14770520_v8_n11_p2543_Gonzalez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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