Synthesis of 6,19-cyclopregnanes. Constrained analogues of steroid hormones

A procedure for the synthesis of 6,19-cyclopregnanes is described involving an intramolecular alkylation reaction of Δ4-3-keto steroids with a 19-mesylate in the presence of KOH in isopropanol. Three 6,19-cyclopregnanes were prepared (4, 5, 9); in the rat, 6,19-cycloprogesterone (4) and its 21-hydro...

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Detalles Bibliográficos
Autores principales:	Di Chenna, P.H., Veleiro, A.S., Sonego, J.M., Ceballos, N.R., Garland, M.T., Baggio, R.F., Burton, G.
Formato:	JOUR
Materias:	Alkylation Derivatives Hormones Synthesis (chemical) Mineralocorticoid receptors Uterus progesterone receptors Organic compounds Rattus
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_14770520_v5_n15_p2453_DiChenna
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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