Enzymatic regioselective and complete deacetylation of two arabinonucleosides

Candida antarctica lipase B (CAL-B)-catalysed regioselective deacetylation of 2′,3′,5′-tri- O-acetyl-1-β- d-arabinofuranosyluracil (1) and 2′,3′,5′-tri- O-acetyl-9-β- d-arabinofuranosyladenine (2) was studied. The choice of the reaction medium allowed the regioselective formation of products bearing...

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Detalles Bibliográficos
Autores principales: Sabaini, M.B., Zinni, M.A., Mohorčič, M., Friedrich, J., Iribarren, A.M., Iglesias, L.E.
Formato: JOUR
Materias:
Keratinase
Lipase
Nucleosides
Prodrugs
Regioselectivity
Candida antarctica lipase B
Deacetylation
Degree of acetylation
Hydrolases
Iso-propanols
Paecilomyces marquandii
Protective group
Reaction medium
Regio-selective
Regioselective deacetylation
Biomolecules
Catalysis
Acetylation
2 propanol
2',3',5' tri o acetyl 1 beta dextro arabinofuranosyluracil
2',3',5' tri o acetyl 9 beta dextro arabinofuranosyladenine
arabinonucleoside
fungal enzyme
hydrolase
keratinase
lipase B
unclassified drug
vidarabine
article
Candida antarctica
catalysis
controlled study
deacetylation
Doratomyces microsporus
drug structure
enzyme assay
enzyme mechanism
enzyme substrate
fungus
nonhuman
paecilomyces marquandii
protein hydrolysis
quantitative analysis
reaction time
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_13811177_v62_n3-4_p225_Sabaini
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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