Preparation of potential 3-deazauridine and 6-azauridine prodrugs through an enzymatic alcoholysis

A set of 3-deazauridine and 6-azauridine peracylated derivatives were regioselectively deacylated through Candida antarctica B lipase (CAL B) catalysed alcoholysis. This biotransformation provided an access to six new 2′,3′-di-O-acylated derivatives of 3-deazauridine and 6-azauridine carrying acetyl...

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Detalles Bibliográficos
Autores principales:	Zinni, M.A., Iglesias, L.E., Iribarren, A.M.
Formato:	JOUR
Materias:	Enzymatic alcoholysis Lipase Nucleosides Prodrugs Regioselectivity Acylation Catalysis Derivatives Enzyme activity Aqueous solubility Biotransformation Deacylation Drug products 3 deazauridine azauridine lipase B nucleoside derivative prodrug alcoholysis aqueous solution article biotransformation Candida antarctica deacylation drug solubility drug stability drug synthesis nonhuman stereochemistry
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_13811177_v47_n1-2_p86_Zinni
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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